Would using CBD melatonin gummies cause heart issues? CBD on its own won’t cause heart problems. Do note that CBD is handled by the liver. While it is being broken down by your liver, it may have an impact on any heart or high blood pressure medications you may be taking. There are articles on Melatonin Ireland Holland and Barrett and Melatonin Ireland Boots on the internet that give some good information on the impact of melatonin on the body and heart if your’e looking for a further source. Both the Melatonin Ireland Holland and Barrett and Melatonin Ireland Boots articles have very similar conclusions and are worth reading. Always consult your doctor before taking anything new, especially if you have a medical condition.